Doctoral Student Alumni:

Kristof Nolan: 2011-2016

1. Coordinated Proliferation and Differentiation of Human-Induced Pluripotent Stem Cell-Derived Cardiac Progenitor Cells Depend on Bone Morphogenetic Protein Signaling Regulation by GREMLIN 2. Bylund JB, Trinh LT, Awgulewitsch CP, Paik DT, Jetter C, Jha R, Zhang J, Nolan K, Xu C, Thompson TB, Kamp TJ, Hatzopoulos AK. Stem Cells Dev. 2017 May 1;26(9):678-693. doi: 10.1089/scd.2016.0226. Epub 2017 Mar 20.

2. Analysis and identification of the Grem2 heparin/heparan sulfate-binding motif. Kattamuri C, Nolan K, Thompson TB. Biochem J. 2017 Mar 8;474(7):1093-1107. doi: 10.1042/BCJ20161050.

3. Structure of Gremlin-2 in Complex with GDF5 Gives Insight into DAN-Family-Mediated BMP Antagonism. Nolan K, Kattamuri C, Rankin SA, Read RJ, Zorn AM, Thompson TB. Cell Rep. 2016 Aug 23;16(8):2077-2086. doi: 10.1016/j.celrep.2016.07.046. Epub 2016 Aug 11.

4. BMP Antagonist Gremlin 2 Limits Inflammation After Myocardial Infarction. Sanders LN, Schoenhard JA, Saleh MA, Mukherjee A, Ryzhov S, McMaster WG Jr, Nolan K, Gumina RJ, Thompson TB, Magnuson MA, Harrison DG, Hatzopoulos AK. Circ Res. 2016 Jul 22;119(3):434-49. doi: 10.1161/CIRCRESAHA.116.308700. Epub 2016 Jun 9.

5. Structure of neuroblastoma suppressor of tumorigenicity 1 (NBL1): insights for the functional variability across bone morphogenetic protein (BMP) antagonists. Nolan K, Kattamuri C, Luedeke DM, Angerman EB, Rankin SA, Stevens ML, Zorn AM, Thompson TB. J Biol Chem. 2015 Feb 20;290(8):4759-71. doi: 10.1074/jbc.M114.628412. Epub 2015 Jan 5.

6. The DAN family: modulators of TGF-β signaling and beyond. Nolan K, Thompson TB. Protein Sci. 2014 Aug;23(8):999-1012. doi: 10.1002/pro.2485. Epub 2014 Jun 2. Review.

7. Structure of protein related to Dan and Cerberus: insights into the mechanism of bone morphogenetic protein antagonism. Nolan K, Kattamuri C, Luedeke DM, Deng X, Jagpal A, Zhang F, Linhardt RJ, Kenny AP, Zorn AM, Thompson TB. Structure. 2013 Aug 6;21(8):1417-29. doi: 10.1016/j.str.2013.06.005. Epub 2013 Jul 11.

8. Members of the DAN family are BMP antagonists that form highly stable noncovalent dimers. Kattamuri C, Luedeke DM, Nolan K, Rankin SA, Greis KD, Zorn AM, Thompson TB. J Mol Biol. 2012 Dec 14;424(5):313-27. doi: 10.1016/j.jmb.2012.10.003. Epub 2012 Oct 9.

9. Structural insight into unique cardiac myosin-binding protein-C motif: a partially folded domain. Howarth JW, Ramisetti S, Nolan K, Sadayappan S, Rosevear PR. J Biol Chem. 2012 Mar 9;287(11):8254-62. doi: 10.1074/jbc.M111.309591. Epub 2012 Jan 10.

10. Structure of myostatin·follistatin-like 3: N-terminal domains of follistatin-type molecules exhibit alternate modes of binding. Cash JN, Angerman EB, Kattamuri C, Nolan K, Zhao H, Sidis Y, Keutmann HT, Thompson TB. J Biol Chem. 2012 Jan 6;287(2):1043-53. doi: 10.1074/jbc.M111.270801. Epub 2011 Nov 3.

Ryan Walker: 2011-2016

1. Structural basis for potency differences between GDF8 and GDF11. Walker RG, Czepnik M, Goebel EJ, McCoy JC, Vujic A, Cho M, Oh J, Aykul S, Walton KL, Schang G, Bernard DJ, Hinck AP, Harrison CA, Martinez-Hackert E, Wagers AJ, Lee RT, Thompson TB. BMC Biol. 2017 Mar 3;15(1):19. doi: 10.1186/s12915-017-0350-1.

2. Biochemistry and Biology of GDF11 and Myostatin: Similarities, Differences, and Questions for Future Investigation. Walker RG, Poggioli T, Katsimpardi L, Buchanan SM, Oh J, Wattrus S, Heidecker B, Fong YW, Rubin LL, Ganz P, Thompson TB, Wagers AJ, Lee RT. Circ Res. 2016 Apr 1;118(7):1125-41; discussion 1142. doi: 10.1161/CIRCRESAHA.116.308391.

3. Myostatin attenuation in vivo reduces adiposity, but activates adipogenesis. Li N, Yang Q, Walker RG, Thompson TB, Du M, Rodgers BD. Endocrinology. 2016 Jan;157(1):282-91. doi: 10.1210/en.2015-1546. Epub 2015 Nov 18.

4. Circulating Growth Differentiation Factor 11/8 Levels Decline With Age. Poggioli T, Vujic A, Yang P, Macias-Trevino C, Uygur A, Loffredo FS, Pancoast JR, Cho M, Goldstein J, Tandias RM, Gonzalez E, Walker RG, Thompson TB, Wagers AJ, Fong YW, Lee RT. Circ Res. 2016 Jan 8;118(1):29-37. doi: 10.1161/CIRCRESAHA.115.307521. Epub 2015 Oct 21.

5. Role of conserved proline residues in human apolipoprotein A-IV structure and function. Deng X, Walker RG, Morris J, Davidson WS, Thompson TB. J Biol Chem. 2015 Apr 24;290(17):10689-702. doi: 10.1074/jbc.M115.637058. Epub 2015 Mar 2.

6. Alternative Binding Modes Identified for Growth and Differentiation Factor-associated Serum Protein (GASP) Family Antagonism of Myostatin. Walker RG, Angerman EB, Kattmuri C, Lee YS, Lee SJ, Thompson TB. J Biol Chem. 2015 Mar 20;290(12):7506-16. doi: 10.1074/jbc.M114.624130. Epub 2015 Feb 5.

7. Fibronectin-based scaffold domain proteins that bind myostatin: a patent evaluation of WO2014043344. Walker RG, Thompson TB. Expert Opinion Ther Pat. 2015 May;25(5):619-24. doi: 10.1517/13543776.2015.1007954. Epub 2015 Jan 29.

8. Myostatin stimulates, not inhibits, C2C12 myoblast proliferation. Rodgers BD, Wiedeback BD, Hoversten KE, Jason MF, Walker RG, Thompson TB. Endocrinology. 2014 Mar;155(3):670-5. doi: 10.1210/en.2013-2107. Epub 2014 Jan 1.

9. The Structure of Human Apolipoprotein A-IV as Revealed by Stable Isotope Assisted Cross-linking, Molecular Dynamics and Small Angle X-ray Scattering. Walker RG, Deng X, Melchior JT, Morris J, Tso P, Jones MK, Segrest JP, Thompson TB, Davidson WS. J Biol Chem. 2014 Feb 28;289(9):5596-608. doi: 10.1074/jbc.M113.541037. Epub 2014 Jan 14.

10. Analysis of the Interaction between Heparin and Follistatin/Follistatin-ligand complexes Using Surface Plasmon Resonance. Zhang F, Beaudet JM, Luedeke DM. Walker RG, Thompson TB, Linhardt RJ. Biochemistry. 51, 6797–6803 Epub 2012 July 19.

Xiaodi 'Andy' Deng: 2007-2013

1. Role of conserved proline residues in human apolipoprotein A-IV structure and function. Deng X, Walker RG, Morris J, Davidson WS, Thompson TB. J Biol Chem. 2015 Apr 24;290(17):10689-702. doi: 10.1074/jbc.M115.637058. Epub 2015 Mar 2.

2. The Structure of Human Apolipoprotein A-IV as Revealed by Stable Isotope Assisted Cross-linking, Molecular Dynamics and Small Angle X-ray Scattering. Walker RG, Deng X, Melchior JT, Morris J, Tso P, Jones MK, Segrest JP, Thompson TB, Davidson WS. J Biol Chem. 2014 Feb 28;289(9):5596-608. doi: 10.1074/jbc.M113.541037. Epub 2014 Jan 14.

3. Structure of protein related to Dan and Cerberus: insights into the mechanism of bone morphogenetic protein antagonism. Nolan K, Kattamuri C, Luedeke DM, Deng X, Jagpal A, Zhang F, Linhardt RJ, Kenny AP, Zorn AM, Thompson TB. Structure. 2013 Aug 6;21(8):1417-29. doi: 10.1016/j.str.2013.06.005. Epub 2013 Jul 11.

4. Small-angle X-ray scattering of apolipoprotein A-IV reveals the importance of its termini for structural stability. Deng X, Morris J, Chaton C, Schroder GF, Davidson WS, Thompson TB. J Biol Chem. 2013 Feb 15;288(7):4854-66. doi: 10.1074/jbc.M112.436709. Epub 2013 Jan 3.

5. The structure of dimeric apolipoprotein A-IV and its mechanism of self-association. Deng X, Morris J, Dressmen J, Tubb MR, Tso P, Jerome WG, Davidson WS, Thompson TB. Structure. 2012 May 9;20(5):767-79. doi: 10.1016/j.str.2012.02.020.

6. Improving the diffraction of apoA-IV crystals through extreme dehydration. Deng X, Davidson WS, Thompson TB. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2012 Jan 1;68(Pt 1):105-10. doi: 10.1107/S1744309111048706. Epub 2011 Dec 24.

Jennifer Cash: 2005-2011

1. Development of a Small-Molecule Screening Method for Inhibitors of Cellular Response to Myostatin and Activin A. Cash JN, Angerman EB, Kirby RJ, Merck L, Seibel WL, Wortman MR, Papoian R, Nelson S, Thompson TB. J Biomol Screen. 2013 Aug;18(7):837-44. doi: 10.1177/1087057113482585. Epub 2013 Mar 29.

2. Characterization of follistatin-type domains and their contribution to myostatin and activin A antagonism. Cash JN, Angerman EB, Keutmann HT, Thompson TB. Mol Endocrinol. 2012 Jul;26(7):1167-78. doi: 10.1210/me.2012-1061. Epub 2012 May 16.

3. Structure of myostatin·follistatin-like 3: N-terminal domains of follistatin-type molecules exhibit alternate modes of binding. Cash JN, Angerman EB, Kattmuri C, Nolan K, Zhao H, Sidis Y, Keutmann HT, Thompson TB. J Biol Chem. 2012 Jan 6;287(2):1043-53. doi: 10.1074/jbc.M111.270801. Epub 2011 Nov 3.

4. The structure of myostatin:follistatin 288: insights into receptor utilization and heparin bindingCash JN, Rejon CA, McPherron AC, Bernard DJ, Thompson TB. EMBO J. 2009 Sep 2;28(17):2662-76. doi: 10.1038/emboj.2009.205. Epub 2009 Jul 30.

POST-DOCTORAL ResearcherS

Robin Stamler 2005-2007

Lei Qian 2016-2017

Technicians

Elizabeth Angerman 2006-2015

David Luedeke 2006-2014